SPRAVATO® (Esketamine) Treatment Information
Overview
Spravato® (esketamine) is an FDA‑approved medication used for adults with treatment‑resistant depression or major depressive disorder with suicidal thoughts.
Spravato® (esketamine) is taken with or without an oral antidepressant for treatment‑resistant depression and alongside an oral antidepressant for major depressive disorder with suicidal thoughts or actions.
It is administered in a certified medical office as a nasal spray under supervision.
Who Is It For
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Adults who have tried at least two antidepressants without adequate relief.
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Adults experiencing severe or persistent depression.
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Adults with major depressive disorder with suicidal thoughts (as part of a larger treatment plan).
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Patients who are medically cleared and appropriate for monitored in‑office treatment.
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How It Works
Spravato® works on a different part of the brain than most antidepressants, a system called glutamate, which helps regulate mood. Because it works differently, it can help people who have not improved with standard medications.
Is Spravato Right for You?
Spravato may be a good fit if you:
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Have tried at least two antidepressants without improvement
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Still experience depression that interferes with daily life.
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Want an alternative treatment backed by science
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Are open to monitored, in-clinic care
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Experience major depressive disorder with suicidal thoughts
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What to Expect During Treatment
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Check‑in and symptom review.
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Provider confirms it is safe to proceed.
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You self‑administer the nasal spray under supervision.
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You rest in a comfortable room while being closely monitored for about 2 hours.
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A ride home is required; driving is not allowed until the next day.
You Will Not Be Alone During Treatment
Our team stays by your side throughout your Spravato session to ensure you feel safe, supported, and informed at every step.
Treatment Schedule
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Weeks 1–4
Two treatments per week
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Weeks 5–8
One treatment per week
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Week 9 +
Every 1–2 weeks depending on progress
Most major insurance plans cover Spravato treatment. Our office handles the insurance prior authorization process for you, verifies your benefits, and reviews any out-of-pocket costs with you before your first session. You don't have to navigate the paperwork alone.
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Dissociation or feeling disconnected
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Dizziness or lightheadedness
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Nausea
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Sleepiness or sedation
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Temporary increase in blood pressure
These effects usually appear shortly after dosing and fade during observation.
Common Side Effects
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Spravato® is only administered in REMS‑certified clinics.
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Patients must stay for monitoring for at least 2 hours.
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A responsible adult must drive you home.
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Traditional medications or therapy may continue alongside Spravato®.
Safety & Requirements
If you are in crisis
If you are experiencing a mental health emergency or having thoughts of harming yourself, call or text 988 for the Suicide and Crisis Lifeline, or go to your nearest emergency room. Spravato is a scheduled treatment and is not a substitute for emergency care.
Your Care at Mental Alive
Your care is personalized and grounded in compassion. We focus on your comfort, safety, and long‑term mental wellness. Treatment plans are tailored to your individual needs and progress.
Care is available in English, Haitian Creole, and French, so you can go through treatment in the language you are most comfortable with.
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